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Association between telomere length and survival in cancer patients: a meta-analysis and review of literature

Xinsen Xu,Kai Qu,Qing Pang,Zhixin Wang,Yanyan Zhou,Chang Liu

Frontiers of Medicine 2016, Volume 10, Issue 2,   Pages 191-203 doi: 10.1007/s11684-016-0450-2

Abstract:

The relationship between telomere length and cancer survival has been widely studied.In conclusion, shortened telomere in peripheral blood and tumor tissue might indicate poor survival fortelomere length ratios of tumor tissue to adjacent normal mucosa, the lower ratio might indicate better survival

Keywords： telomere     survival     cancer     meta-analysis    

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Influence of the adjuvant therapy on the survival of patients with stage II pancreatic carcinoma

Xi-Yan WANG, Hai-Jun LI, Dong YAN, Hao WEN, Shu-Yong PENG,

Frontiers of Medicine 2010, Volume 4, Issue 4,   Pages 430-435 doi: 10.1007/s11684-010-0700-7

Abstract: The overall 1-, 3-, and 5-year cumulative survival rates of 139 patients were 40%, 6%, and 3%, respectively, and the median survival time (MST) was 279 days.The adjuvant therapy could not prolong the survival time and decrease the liver metastasis rate of thebypass operation and laparotomy group and nonsurgical group, the adjuvant therapy could improve the survivalof the patients significantly (<0.05); however, the survival rate was not significantly different

Keywords： pancreatic neoplasms     neoadjuvant therapy     survival    

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Multi-stage emergency medicine logistics system optimization based on survival probability

Ke WANG, Yixin LIANG, Lindu ZHAO

Frontiers of Engineering Management 2017, Volume 4, Issue 2,   Pages 221-228 doi: 10.15302/J-FEM-2017020

Abstract: Using sudden cardiac deaths as an example and maximizing survival rate as the goal, this paper studiesthe influence of multi-stage medical logistics system optimization on the survival rate of sudden illnessA distribution model of survival is built, drone and ambulance arrival probability over time are discussed, a formula is proposed for maximum possible survival rate based on the probability of emergency medicaldrones delivering medical equipment for first aid on-site in emergencies can significantly increase survival

Keywords： emergency medicine logistics     ambulance drone     survival probability     critical illness    

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Construction of an immortalized neural progenitor cell strain and analysis of its immunogenicity

AN Ke, XU Ying, TIAN Xuebi, GAO Feng, TIAN Yuke, YANG Hui, ZHANG Chuanhan

Frontiers of Medicine 2008, Volume 2, Issue 1,   Pages 63-69 doi: 10.1007/s11684-008-0012-3

Abstract: The immortalized cells may show good long-term survival and do not elicit an acute immunological response

Keywords： immortalized     long-term survival     differentiation     capacity     genotype    

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Palmitoylation of GNAQ/11 is critical for tumor cell proliferation and survival in GNAQ/11-mutant uveal

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 784-798 doi: 10.1007/s11684-021-0911-0

Abstract: revealed that the loss of GNAQ/11 palmitoylation substantially affected tumor cell proliferation and survivalin UM cells, which are much more dependent on Gαq/11 signaling for cell survivalstrong>αq/11 downstream signaling by interfering with the MAPK pathway and BCL2 survival

Keywords： uveal melanoma     mutant GNAQ/11     palmitoylation     BCL2     combination target therapy    

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Association of SIPA1 545 C>T polymorphism with survival in Chinese women with metastatic breast cancer

Renling Pei, Ye Xu, Yan Wei, Tao Ouyang, Jinfeng Li, Tianfeng Wang, Zhaoqing Fan, Tie Fan, Benyao Lin, Yuntao Xie

Frontiers of Medicine 2013, Volume 7, Issue 1,   Pages 138-142 doi: 10.1007/s11684-013-0247-5

Abstract: study was to determine whether SIPA1 545 C>T polymorphism was associated with overall survivalSurvival curves for patients with SIPA1 545 C>T polymorphism was compared using the Kaplan-MeierWe found that SIPA1 545 C>T polymorphism was significantly associated with survival in 185Patients with SIPA1545 T/T genotype had a significantly worse overall survival (OS) than did patientsMoreover, in multivariate analysis, as compared with the C/C or C/T genotype, the T/T genotype remained

Keywords： SIPA1     polymorphism     metastatic breast cancer     survival    

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Intracellular trehalose improves the survival of human red blood cells by freeze-drying

HE Hui, LIU Baolin, HUA Zezhao, LI Chuan, WU Zhengzheng

Frontiers in Energy 2007, Volume 1, Issue 1,   Pages 120-124 doi: 10.1007/s11708-007-0014-x

Abstract: The aim of this study was to investigate the effects of intracellular trehalose on the survival of red
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Transcriptional modules related to hepatocellular carcinoma survival: coexpression network analysis

Xinsen Xu,Yanyan Zhou,Runchen Miao,Wei Chen,Kai Qu,Qing Pang,Chang Liu

Frontiers of Medicine 2016, Volume 10, Issue 2,   Pages 183-190 doi: 10.1007/s11684-016-0440-4

Abstract:

We performed weighted gene coexpression network analysis (WGCNA) to gain insights into the molecularCorrelation and survival analyses were conducted using the modules, and gene ontology (GO) enrichmentIn addition, GO enrichment analysis suggested that inflammation, immune, virus-related, and interferon-mediated

Keywords： hepatocellular carcinoma     coexpression     module     microarray     prognosis    

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Liver-directed treatment is associated with improved survival and increased response to immune checkpoint

Frontiers of Medicine   Pages 878-888 doi: 10.1007/s11684-023-0993-y

Abstract: 182 patients with metastatic UM treated with immune checkpoint blockade (ICB) were included in this analysisData were analyzed for response to treatment, progression-free survival (PFS), and overall survival (Our data suggest that the combination of LDT with ICB may be associated with a survival benefit and higher

Keywords： uveal melanoma     liver-directed therapy     immune checkpoint blockade     SIRT     anti-PD-1     anti-CTLA-4    

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platinum for elderly patients with advanced non-squamous non-small-cell lung cancer: a retrospective analysis

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 610-617 doi: 10.1007/s11684-021-0827-8

Abstract: For the entire cohort of patients, the median OS was 33.3 months, and the 1-year and 2-year overall survivalWith increased toxicities, the addition of bevacizumab to PP does not improve the overall survival of

Keywords： bevacizumab     elderly patient     advanced non-small-cell lung cancer     overall survival     toxicity    

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Science and Technology in Human's Living and Survival in the 21st Century

Jiang Zhenghua

Strategic Study of CAE 2002, Volume 4, Issue 4,   Pages 1-11

Abstract:

This article, from the angle of management, reviews the world history over the past century, studies the prospective progress in the new century, and discusses ways for promoting world peace and cooperation and realizing common development.

Keywords： 21st century     progress in science and technology     human's living and survival    

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Different sites of extranodal involvement may affect the survival of patients with relapsed or refractory

Lili Zhou, Ping Li, Shiguang Ye, Xiaochen Tang, Junbang Wang, Jie Liu, Aibin Liang

Frontiers of Medicine 2020, Volume 14, Issue 6,   Pages 786-791 doi: 10.1007/s11684-020-0751-3

Abstract: this study, we found that the different sites of extranodal involvement may affect response, overall survival(OS), and progression-free survival (PFS) in patients with r/r NHL treated with anti-CD19 CAR-T cellsThe factors that may affect prognosis were identified through multivariable analysis.

Keywords： anti-CD19 chimeric antigen receptor T cell     soft tissue     bone marrow     relapsed or refractory non-Hodgkin lymphoma    

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Arsenic in the treatment of newly diagnosed acute promyelocytic leukemia: current status and future research direction

Jiong HU

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 45-52 doi: 10.1007/s11684-011-0117-y

Abstract: introduction of all-trans retinoic acid to conventional chemotherapy improved dramatically the remission and survivalIn the last decade, the groundbreaking development of arsenic further improved the survival rate of APL

Keywords： acute promyelocytic leukemia     arsenic     all-trans retinoic acid     survival    

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Potential indicators predict progress after surgical resection of gastrointestinal stromal tumors

Qinggang Hu, Shanglong Liu, Jianwei Jiang, Chen Zhang, Xiaowei Liu, Qichang Zheng

Frontiers of Medicine 2012, Volume 6, Issue 3,   Pages 317-321 doi: 10.1007/s11684-012-0203-9

Abstract: Their 3-year survival rate were 65.3% and 41.3%, respectively (P<0.001).Moreover, tumor size and mitotic index were associated with free survival.The 3-year survival rate for patients with tumor size≤10 cm and>10 cm were 62.3% and 41.8%, respectively(P = 0.002), Tumors with mitotic index≤5/50 HPF had a higher 3-year survival rate than tumorsThe 3-year survival rate for presence and absence necrosis were 50.8% and 64.8% (P = 0.008).

Keywords： gastrointestinal stromal tumors     surgery     survival    

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Pleckstrin Homology-Like Domain, Family A, Member 1 (PHLDA1): A Multifaceted Cell Survival Factor that Review

Tamana Yousof, Jae Hyun Byun, Jack Chen, Richard C. Austin

Engineering 2023, Volume 20, Issue 1,   Pages 9-18 doi: 10.1016/j.eng.2022.05.014

Abstract:

Pleckstrin homology-like domain, family A, member 1 (PHLDA1) is a multifaceted intracellular protein belonging to the evolutionarily conserved pleckstrin homology-related domain family. Its murine homologue, T-cell death-associated 51 (TDAG51) gene, was initially discovered for its role in activation-induced apoptosis in T-cell hybridomas. In recent years, PHLDA1 has received increased attention due to its association with obesity, fatty liver disease, diabetes, atherosclerosis, and cancer. Accumulating evidence also supports its role in endoplasmic reticulum stress signaling pathways as a crucial mediator of apoptosis, autophagy, and cell proliferation. In this review, the current knowledge of PHLDA1 gene and protein regulation, localization, and function is summarized. This review highlights the pro- and anti-apoptotic roles of PHLDA1 that contribute to vast array of metabolic diseases.

Keywords： ER-stress     Metabolism     Apoptosis     Cell survival     PHLDA1    

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Title Author Date Type Operation

Association between telomere length and survival in cancer patients: a meta-analysis and review of literature

Xinsen Xu,Kai Qu,Qing Pang,Zhixin Wang,Yanyan Zhou,Chang Liu

Journal Article

Influence of the adjuvant therapy on the survival of patients with stage II pancreatic carcinoma

Xi-Yan WANG, Hai-Jun LI, Dong YAN, Hao WEN, Shu-Yong PENG,

Journal Article

Multi-stage emergency medicine logistics system optimization based on survival probability

Ke WANG, Yixin LIANG, Lindu ZHAO

Journal Article

Construction of an immortalized neural progenitor cell strain and analysis of its immunogenicity

AN Ke, XU Ying, TIAN Xuebi, GAO Feng, TIAN Yuke, YANG Hui, ZHANG Chuanhan

Journal Article

Palmitoylation of GNAQ/11 is critical for tumor cell proliferation and survival in GNAQ/11-mutant uveal

Journal Article

Association of SIPA1 545 C>T polymorphism with survival in Chinese women with metastatic breast cancer

Renling Pei, Ye Xu, Yan Wei, Tao Ouyang, Jinfeng Li, Tianfeng Wang, Zhaoqing Fan, Tie Fan, Benyao Lin, Yuntao Xie

Journal Article

Intracellular trehalose improves the survival of human red blood cells by freeze-drying

HE Hui, LIU Baolin, HUA Zezhao, LI Chuan, WU Zhengzheng

Journal Article

Transcriptional modules related to hepatocellular carcinoma survival: coexpression network analysis

Xinsen Xu,Yanyan Zhou,Runchen Miao,Wei Chen,Kai Qu,Qing Pang,Chang Liu

Journal Article

Liver-directed treatment is associated with improved survival and increased response to immune checkpoint

Journal Article

platinum for elderly patients with advanced non-squamous non-small-cell lung cancer: a retrospective analysis

Journal Article

Science and Technology in Human's Living and Survival in the 21st Century

Jiang Zhenghua

Journal Article

Different sites of extranodal involvement may affect the survival of patients with relapsed or refractory

Lili Zhou, Ping Li, Shiguang Ye, Xiaochen Tang, Junbang Wang, Jie Liu, Aibin Liang

Journal Article

Arsenic in the treatment of newly diagnosed acute promyelocytic leukemia: current status and future research direction

Jiong HU

Journal Article

Potential indicators predict progress after surgical resection of gastrointestinal stromal tumors

Qinggang Hu, Shanglong Liu, Jianwei Jiang, Chen Zhang, Xiaowei Liu, Qichang Zheng

Journal Article

Pleckstrin Homology-Like Domain, Family A, Member 1 (PHLDA1): A Multifaceted Cell Survival Factor that

Tamana Yousof, Jae Hyun Byun, Jack Chen, Richard C. Austin

Journal Article